1) There will be two main characters (Vito and Joe). Vito will be the only playable one but Joe is supposed to be important as well.
2) There will be no story connection between Mafia 1 and 2.
3) There will be extensive car damage. Says better then Burnout Paradise. It will have exploding fuel tanks.
4) You will visit the gas station for gas and to wash your car so it becomes shinny.
5) Money will be very important. New clothes will help if someone is after you. Food will make you stronger like in GTA San Andreas.
6) Cover system like in Gears of War.
7) Setting will be Empire City. Twice as big as City of Lost Heaven. It will resemble San Francisco.
8) The lead platforms will be Ps3 and Xbox 360. Pc version may be few weeks or months later. But this may change.
9) Release date Spring/ Summer 2009.
10) The story starts before the end of WWII.