BioWare has confirmed that the next Mass Effect will use the latest version of DICE’s Frostbite engine. In a blog post on BioWare’s official site, BioWare Montreal studio director Yanick Roy said the following lines about the next Mass Effect:
"It will be built with the amazing technology of Frostbite as its foundation, enhanced by many of the systems that the Dragon Age III team has already spent a lot of time building.
The other thing I can tell you is that, while it will be very respectful of the heritage built over the course of the first three games, with the original trilogy now concluded and the switch over to a new engine, we are exploring new directions, both on the gameplay and story fronts. You can still expect the pillars the franchise is known for to be fully intact though, including diverse alien races, a huge galaxy to explore, and of course rich, cinematic storytelling.
Earlier this week, Mass Effect producer Casey Hudson confirmed that the Mass Effect 4 is in development.